Cell size control is sirtuin(ly) exciting
نویسندگان
چکیده
منابع مشابه
Cell size control is sirtuin(ly) exciting
In the classic essay ‘On longevity and shortness of life’Aristotle speculated on the causes of the length or brevity of lifespan. More than 23 centuries ago, he postulated that three factors have major effects on longevity: metabolic rate, reproductive rate, and size. Remarkably, these observations still hold true. However, the molecular and genetic mechanisms that are responsible for these fun...
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Cells of a given type maintain a characteristic cell size to function efficiently in their ecological or organismal context. They achieve this through the regulation of growth rates or by actively sensing size and coupling this signal to cell division. We focus this review on potential size-sensing mechanisms, including geometric, external cue, and titration mechanisms. Mechanisms that titrate ...
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Cells usually grow to a proper size before they divide. To ensure an optimal size for cell survival and function, it is crucial that cells develop efficient and sensitive mechanisms for cell-size control. in 2009, 2 independent studies proposed that the DyRK-family kinase Pom1 could serve as a cell-length sensor to negatively regulate mitotic entry through sAD-like kinase Cdr2 in fission yeast....
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Bacteria proliferate by repetitive cycles of cellular growth and division. The progression into the cell cycle is admitted to be under the control of cell size. However, the molecular basis of this regulation is still unclear. Here I will discuss which mechanisms could allow coupling growth and division by sensing size and transmitting this information to the division machinery. Size sensors co...
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Cell size is an important adaptive trait that influences nearly all aspects of cellular physiology. Despite extensive characterization of the cell-cycle regulatory network, the molecular mechanisms coupling cell growth to division, and thereby controlling cell size, have remained elusive. Recent work in yeast has reinvigorated the size control field and suggested provocative mechanisms for the ...
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ژورنال
عنوان ژورنال: Molecular Systems Biology
سال: 2013
ISSN: 1744-4292,1744-4292
DOI: 10.1038/msb.2013.64